Avocado Paste is one of the effective Natural Remedies for Granuloma Annulare reason that avocado doubtless works on granuloma annulare is that it’s packed with vitamin E. Mash up an avocado and blend it well with enough olive oil so that it’s smooth and nice. Apply it to your lesions every day. Allow it to settle on your skin for at least half an hour before cleaning it off.